Propane, 1-bromo-3-fluoro- → HCID 18705898, compound

Participants

Reaction Steps

Using procedure 44, 2-(Dipropylamino)-2,3-dihydro-6-hydroxy-1H-indene-5-carboxamide (87, 0.19 g, 0.7 mmol) was treated with 1-bromo-3-fluoropropane (0.296 g, 2.1 mmol). Chromatographic purification yielded pure product 89 as a oil which was converted into the HCl salt and crystallized from EtOAc/MeOH to give a white solid (m.p. 219-220° C.).

Provenance & Evidence