Hydrochloric Acid → HCID 18705827, compound

HRID 2287855Notes

Reaction equation

HRID 2287855 reaction equation
[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([C:17]([O-:19])=O)=[C:10]([C:14]([O-])=[O:15])[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3].[Cl:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][NH2:29])=[CH:26][CH:25]=1.Cl>>[Cl:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][N:29]2[C:14](=[O:15])[C:10]3[CH:11]=[C:12]4[CH2:13][CH:5]([N:4]([CH2:20][CH2:21][CH3:22])[CH2:1][CH2:2][CH3:3])[CH2:6][C:7]4=[CH:8][C:9]=3[C:17]2=[O:19])=[CH:26][CH:25]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 660364-ChlorobenzylamineHCID 18705881HCID 18705881, compound

Product 1

HCID 18705827HCID 18705827, compound

Procedure

Using procedure 49, 2-(dipropylamino)-2,3-dihydro-1H-indene-5,6-dicarboxylate (92, 0.35 g, 1.0 mmol) was treated with 4-chlorobenzylamine (0.17 mL, 1.4 mmol). Purification using silica gel, eluting with 5:1 hexane/acetone, afforded an oil that was converted to an HCl salt and recrystallized from hot MeOH/EtOAc to give 102 as a white solid (m.p. 260-261° C.).

Workup

  1. customPurification
  2. washeluting with 5:1 hexane/acetone
  3. customafforded an oil that
  4. customrecrystallized from hot MeOH/EtOAc

Sources & evidence

ORD record
ord-70eb2de7a64c409c856b3b4ec5462e32
Source dataset
uspto-grants-2000_07
Patent number
US06084130

Reaction notes

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