Hydrochloric Acid → HCID 18705834, compound

HRID 2287866Notes

Reaction equation

HRID 2287866 reaction equation
[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([C:17]([O-:19])=O)=[C:10]([C:14]([O-:16])=O)[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3].[NH2:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1.Cl>>[CH2:20]([N:4]([CH2:1][CH2:2][CH3:3])[CH:5]1[CH2:6][C:7]2=[CH:8][C:9]3[C:17](=[O:19])[N:23]([CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=4)[C:14](=[O:16])[C:10]=3[CH:11]=[C:12]2[CH2:13]1)[CH2:21][CH3:22]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 195092-PyridinemethanamineHCID 18705881HCID 18705881, compound

Product 1

HCID 18705834HCID 18705834, compound

Procedure

Using procedure 49, 2-(dipropylamino)-2,3-dihydro-1H-indene-5,6-dicarboxylate (92, 0.35 g, 1.0 mmol) was treated with 2-aminomethylpyridine (0.4 mL, 4.0 mmol). Purification via using silica gel, eluting with 2:1 CH2Cl2 /acetone, afforded an oil that was converted to an HCl salt and recrystallized from hot MeOH/EtOAc to give 115 as a white solid (m.p. 130-135° C.).

Workup

  1. customPurification
  2. washeluting with 2:1 CH2Cl2 /acetone
  3. customafforded an oil that
  4. customrecrystallized from hot MeOH/EtOAc

Sources & evidence

ORD record
ord-467934d0b64b40e1970fed586eeb81ca
Source dataset
uspto-grants-2000_07
Patent number
US06084130

Reaction notes

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