Hydrochloric Acid → HCID 18705850, compound

HRID 2287870Notes

Reaction equation

HRID 2287870 reaction equation
[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([C:17]([O-])=[O:18])=[C:10]([C:14]([O-:16])=O)[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3].[S:23]1[CH:27]=[CH:26][CH:25]=[C:24]1[CH2:28][NH2:29].Cl>>[CH2:20]([N:4]([CH2:1][CH2:2][CH3:3])[CH:5]1[CH2:13][C:12]2=[CH:11][C:10]3[C:14](=[O:16])[N:29]([CH2:28][C:24]4[S:23][CH:27]=[CH:26][CH:25]=4)[C:17](=[O:18])[C:9]=3[CH:8]=[C:7]2[CH2:6]1)[CH2:21][CH3:22]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 34005(2-Thienylmethyl)amineHCID 18705881HCID 18705881, compound

Product 1

HCID 18705850HCID 18705850, compound

Procedure

Using procedure 49, 2-(dipropylamino)-2,3-dihydro-1H-indene-5,6-dicarboxylate (92, 0.35 g, 1.0 mmol) was treated with 2-thiophene-methylamine (0.13 mL, 1.3 mmol). Purification using silica gel, eluting with 3:1 CH2Cl2/acetone, afforded an oil that was converted to an HCl salt and recrystallized from hot MeOH/EtOAc to give 119 as a white solid (m.p. 220-225° C.).

Workup

  1. customPurification
  2. washeluting with 3:1 CH2Cl2/acetone
  3. customafforded an oil that
  4. customrecrystallized from hot MeOH/EtOAc

Sources & evidence

ORD record
ord-0ec38ee573b0458aadebbb42c12cb835
Source dataset
uspto-grants-2000_07
Patent number
US06084130

Reaction notes

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