Hydrochloric Acid → HCID 18705873, compound

HRID 2287871Notes

Reaction equation

HRID 2287871 reaction equation
[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([C:17]([O-])=[O:18])=[C:10]([C:14]([O-])=[O:15])[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3].Cl.[CH3:24][NH2:25].Cl>>[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:13][C:12]2=[CH:11][C:10]3[C:14](=[O:15])[N:25]([CH3:24])[C:17](=[O:18])[C:9]=3[CH:8]=[C:7]2[CH2:6]1)[CH2:2][CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6364545Methylamine hydrochlorideHCID 18705881HCID 18705881, compound

Product 1

HCID 18705873HCID 18705873, compound

Procedure

Using procedure 49, 2-(dipropylamino)-2,3-dihydro-1H-indene-5,6-dicarboxylate (92, 0.3 g, 1.0 mmol) was treated with methylamine hydrochloride(1.35 g, 20.0 mmol). Purification on silica gel, eluting with 2:1 hexane/acetone, afforded an oil that was converted to an HCl salt and recrystallized from EtOAc/2-propanol to give 120 as a white solid (m.p. 245-246° C.).

Workup

  1. customPurification on silica gel
  2. washeluting with 2:1 hexane/acetone
  3. customafforded an oil that
  4. customrecrystallized from EtOAc/2-propanol

Sources & evidence

ORD record
ord-49b4934895374e27a2d1c223ec6fde93
Source dataset
uspto-grants-2000_07
Patent number
US06084130

Reaction notes

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