Trifluoroacetic acid → HCID 54359131, compound

Participants

Reaction Steps

To a solution of N-[(1R)-2-(N'-acetyl-N-methylhydrazino)-1-benzyl-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester (0.35 g, 1.00 mmol) in methylene chloride (2 ml) was added trifluoroacetic acid (2 ml) and the mixture was stirred for 30 min. The mixture was concentrated in vacuo and stripped three times with methylene chloride and chromatographed on silca gel (40 g) with methylene chloride:(methanol/ammonia) (9:1) to give 110 mg (44%) of acetic acid N'-methyl-N'-((2R)-2-(methylamino)-3-phenylpropionyl)hydrazide as an oil.

Provenance & Evidence