反应详情

To a solution of N-[(1R)-2-(N'-acetyl-N-methylhydrazino)-1-benzyl-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester (0.35 g, 1.00 mmol) in methylene chloride (2 ml) was added trifluoroacetic acid (2 ml) and the mixture was stirred for 30 min. The mixture was concentrated in vacuo and stripped three times with methylene chloride and chromatographed on silca gel (40 g) with methylene chloride:(methanol/ammonia) (9:1) to give 110 mg (44%) of acetic acid N'-methyl-N'-((2R)-2-(methylamino)-3-phenylpropionyl)hydrazide as an oil.

1. concentrationThe mixture was concentrated in vacuo
2. customchromatographed on silca gel (40 g) with methylene chloride