Methyl formate → HCID 18704597, compound

HRID 2287908Notes

Reaction equation

HRID 2287908 reaction equation
[NH2:1][N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:8][O:9]C=O>>[N:2]1([NH:1][CH:8]=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 7865Methyl formateHCID 166581-Aminopiperidine

Product 1

HCID 18704597HCID 18704597, compoundYield 77.6%

Procedure

A solution of N-aminopiperidine (2.0 ml, 18.5 mmol) and methylformate (2.3 ml, 37 mmol) was stirred for four days in a sealed tube at 40° C. The mixture was concentrated in vacuo, suspended in ether (100 ml) and filtered to give 1.84 g of N-(piperidin-1-yl)formamide as a white powder.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. filtrationfiltered

Sources & evidence

ORD record
ord-36519295d61d4357bb3c7f29b9f90113
Source dataset
uspto-grants-2000_07
Patent number
US06083908

Reaction notes

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