Guanidine → HCID 178478828, compound

HRID 2287948Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][C:17]3[CH:18]=[C:19]4[C:24](=[CH:25][CH:26]=3)[CH:23]=[C:22]([C:27](O)=[O:28])[CH:21]=[CH:20]4)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[NH2:30][C:31]([NH2:33])=[NH:32]>>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][C:17]3[CH:18]=[C:19]4[C:24](=[CH:25][CH:26]=3)[CH:23]=[C:22]([C:27]([NH:32][C:31]([NH2:33])=[NH:30])=[O:28])[CH:21]=[CH:20]4)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 3520Guanidine

HCID 18702910HCID 18702910, compound

Product 1

HCID 178478828HCID 178478828, compound

Procedure

2.4 g of 6-{2-[4-(4-chlorophenyl)-1-piperazinyl]-ethoxy}-2-naphthoic acid are reacted with CDl and guanidine according to the general procedure (variant 1 a). 1.4 g of 6-{2-[4-(4-chlorophenyl)-1-piperazinyl]-ethoxy}-2-naphthoylguanidine dihydrochloride are obtained; m.p.: 269-271° C.

Sources & evidence

ORD record: ord-cafbeea1f0484d63b1b50ddbf3c78335
Source dataset: uspto-grants-2000_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06087304

Reaction notes

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