Hydrochloric Acid → HCID 131721865, compound

HRID 2288001Notes

Reaction equation

HRID 2288001 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12]([S:15]([N:18]([CH2:30][CH2:31][N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)[C@@H:19]([C:23]([O:25]C(C)(C)C)=[O:24])[CH:20]([CH3:22])[CH3:21])(=[O:17])=[O:16])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[ClH:38]>O>[ClH:38].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8][C:9]2[CH:10]=[CH:11][C:12]([S:15]([N:18]([CH2:30][CH2:31][N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)[C@@H:19]([C:23]([OH:25])=[O:24])[CH:20]([CH3:22])[CH3:21])(=[O:17])=[O:16])=[CH:13][CH:14]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53954406HCID 53954406, compound

Product 1

HCID 131721865HCID 131721865, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of N-[[4-[(4-methylphenyl)thio]-phenyl]sulfonyl]-N-[2-(4-morpholinyl)ethyl]-D-valine, 1,1-dimethylethyl ester, from Example 2b (3.5 g, 6.4 mmole) in water (50 ml) was added concentrated HCl (50 ml). After stirring for 1 hour at room temperature for 30 minutes under reflux, the reaction was concentrated to give N-[[4-[(4-methylphenyl)thio]phenyl]sulfonyl]-N-[2-(4-morpholinyl)-ethyl]-D-valine, monohydrochloride, as a white foam (3.5 g, 100%): MS MH+ calc'd for C24H32N2S2O5 ; 493, found: 493.

Workup

  1. temperatureunder reflux
  2. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-951722f287b945b2b1c2b72d68f6c65f
Source dataset
uspto-grants-2000_07
Patent number
US06087359

Reaction notes

Loading…