Hydrochloric Acid → HCID 131721866, compound

Participants

Reaction Steps

N-[2-(4-morpholinyl)ethyl]-N-[[4-(phenylthio)-phenyl]sulfonyl]-D-alanine, 1,1-dimethylethyl ester from Example 3d (4.33 g, 8.55 mmol) in 6 N HCl (71 mL) was refluxed for 20 minutes, and upon cooling to room temperature a white solid precipitated. The solid was collected, washed with water, and dried in a 40° C. vacuum oven to give N-[2-(4-morpholinyl)ethyl]-N-[[4-(phenylthio)-phenyl]sulfonyl]-D-alanine, monohydrochloride, as a white solid (2.38 g, 57% yield): anal. calc'd for C21H26N2O5S2.1.2HCl: C, 51.02; H, 5.55; N, 5.67. Found: C, 50.94; H, 5.41; N, 5.57.

Provenance & Evidence