Hydrochloric Acid → HCID 131721866, compound

HRID 2288003Notes

Reaction equation

HRID 2288003 reaction equation
[N:1]1([CH2:7][CH2:8][N:9]([S:19]([C:22]2[CH:27]=[CH:26][C:25]([S:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:24][CH:23]=2)(=[O:21])=[O:20])[C@@H:10]([C:12]([O:14]C(C)(C)C)=[O:13])[CH3:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[ClH:35]>>[ClH:35].[N:1]1([CH2:7][CH2:8][N:9]([S:19]([C:22]2[CH:27]=[CH:26][C:25]([S:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:24][CH:23]=2)(=[O:21])=[O:20])[C@@H:10]([C:12]([OH:14])=[O:13])[CH3:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 53920520HCID 53920520, compound

Product 1

HCID 131721866HCID 131721866, compound

Procedure

N-[2-(4-morpholinyl)ethyl]-N-[[4-(phenylthio)-phenyl]sulfonyl]-D-alanine, 1,1-dimethylethyl ester from Example 3d (4.33 g, 8.55 mmol) in 6 N HCl (71 mL) was refluxed for 20 minutes, and upon cooling to room temperature a white solid precipitated. The solid was collected, washed with water, and dried in a 40° C. vacuum oven to give N-[2-(4-morpholinyl)ethyl]-N-[[4-(phenylthio)-phenyl]sulfonyl]-D-alanine, monohydrochloride, as a white solid (2.38 g, 57% yield): anal. calc'd for C21H26N2O5S2.1.2HCl: C, 51.02; H, 5.55; N, 5.67. Found: C, 50.94; H, 5.41; N, 5.57.

Workup

  1. customprecipitated
  2. customThe solid was collected
  3. washwashed with water
  4. customdried in a 40° C. vacuum oven

Sources & evidence

ORD record
ord-777b4af75e104fcea0d00922895f26c4
Source dataset
uspto-grants-2000_07
Patent number
US06087359

Reaction notes

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