Sulfuryl chloride → HCID 86755503, compound

HRID 2288014Notes

Reaction equation

HRID 2288014 reaction equation
[CH3:1][N:2]1[C:16]2[C:17]3[C:4]([CH2:5][C@@H:6]4[C@@:11]([O:18][CH3:19])([C:12]=3[CH:13]=[CH:14][CH:15]=2)[CH2:10][C@@:9]([C:21]2[O:25][N:24]=[C:23]([C:26]3[CH:27]=[N:28][CH:29]=[C:30]([Br:32])[CH:31]=3)[N:22]=2)([CH3:20])[CH2:8][N:7]4[CH3:33])=[CH:3]1.S(Cl)([Cl:37])(=O)=O>C(#N)C>[CH3:1][N:2]1[C:16]2[C:17]3[C:4]([CH2:5][C@@H:6]4[C@@:11]([O:18][CH3:19])([C:12]=3[CH:13]=[CH:14][CH:15]=2)[CH2:10][C@@:9]([C:21]2[O:25][N:24]=[C:23]([C:26]3[CH:27]=[N:28][CH:29]=[C:30]([Br:32])[CH:31]=3)[N:22]=2)([CH3:20])[CH2:8][N:7]4[CH3:33])=[C:3]1[Cl:37]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 86755504HCID 86755504, compound

Product 1

HCID 86755503HCID 86755503, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

To a stirred solution of 2 g of 1,6-dimethyl-8β-methyl[3-(5-bromo-pyridin-3-yl)-1,2,4-oxadiazol-5-yl]-10α-methoxy-ergoline in ml 50 of acetonitrile and ml 0.5 of BF3-2 Et2O was added dropwise a solution of 0.6 g of sulphuryichloride (SO2Cl2) in ml 15 of acetonitrile at -5° C.

Sources & evidence

ORD record
ord-4dd7f97a94244bc7a8a4b77d2db38c01
Source dataset
uspto-grants-2000_07
Patent number
US06087371

Reaction notes

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