Hydrochloric Acid → HCID 23000863, compound

HRID 2288025Notes

Reaction equation

HRID 2288025 reaction equation
C([S:4][CH:5]1[CH2:10][CH2:9][N:8]([CH:11]([C:19]([CH:21]2[CH2:23][CH2:22]2)=[O:20])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[CH2:7][CH2:6]1)(=O)C.[ClH:24]>C(O)C>[ClH:24].[CH:21]1([C:19]([CH:11]([N:8]2[CH2:7][CH2:6][CH:5]([SH:4])[CH2:10][CH2:9]2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[O:20])[CH2:23][CH2:22]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15462945HCID 15462945, compound

Product 1

HCID 23000863HCID 23000863, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of ethanol, 2.00 g (5.97 mmol) of 4-acetylthio-1-(α-cyclopropylcarbonyl-2-fluorobenzyl)piperidine were dissolved. An adequate amount of hydrogen chloride gas was blown into this solution and the resulting solution was allowed to stand overnight at room temperature. The solvent was distilled off under reduced pressure. The residue was crystallized from diethyl ether, whereby 1.95 g of the title compound were obtained as slightly brown crystals (yield: 99%).

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customThe residue was crystallized from diethyl ether

Sources & evidence

ORD record
ord-3aaa5ffa648e4ea48ad79c5ad1eb666e
Source dataset
uspto-grants-2000_07
Patent number
US06087379

Reaction notes

Loading…