Thionyl Chloride → HCID 22342920, compound

HRID 2288194Notes

Reaction equation

HRID 2288194 reaction equation
S(Cl)([Cl:3])=O.[O:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]#[C:13][CH2:14]O)[CH2:7][CH2:6]1>ClCCl>[ClH:3].[O:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]#[C:13][CH2:14][Cl:3])[CH2:7][CH2:6]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 31128494-Morpholinobut-2-YN-1-OL

Product 1

HCID 22342920HCID 22342920, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride (2.1 ml) was added to a solution of 4-morpholino-2-butyn-1-ol (1.47 g) in dichloromethane (10 ml) with ice bath cooling. After stirring for 0.5 hour, the solution was evaporate din vacuo. The residue was triturated with ethyl acetate to give 4-morpholino-2-butynyl chloride hydrochloride (1.91 g).

Workup

  1. temperaturecooling
  2. customthe solution was evaporate din vacuo
  3. customThe residue was triturated with ethyl acetate

Sources & evidence

ORD record
ord-934a48dd08f942d89baafcaaa59998c3
Source dataset
uspto-grants-2000_07
Patent number
US06087357

Reaction notes

Loading…