反应详情

Thionyl chloride (2.1 ml) was added to a solution of 4-morpholino-2-butyn-1-ol (1.47 g) in dichloromethane (10 ml) with ice bath cooling. After stirring for 0.5 hour, the solution was evaporate din vacuo. The residue was triturated with ethyl acetate to give 4-morpholino-2-butynyl chloride hydrochloride (1.91 g).

1. temperaturecooling
2. customthe solution was evaporate din vacuo
3. customThe residue was triturated with ethyl acetate