反应详情

To an ice-cooled solution of ethyl 3-(1-methyl-1H-pyrazol-4-yl)propionate (1.05 g) in tetrahydrofuran (10 ml) was added lithium aluminum hydride (0.22 g) under nitrogen atmosphere After the mixture was stirred for 30 minutes, water and 15% sodium hydroxide aqueous solution were added successively to the mixture. The resulting precipitates were filtered off through Celite® pad and the filtrate was extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate and concentrated under reduced pressure to give 3-(1-methyl-1H-pyrazol-4-yl)-1-propanol.

1. customThe resulting precipitates
2. filtrationwere filtered off through Celite® pad
3. extractionthe filtrate was extracted with ethyl acetate
4. washThe organic layer was washed with water
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated under reduced pressure