Hydrochloric Acid → 2-(Pyridin-2-yl)quinoline-4-carboxylic acid

HRID 2288281Notes

Reaction equation

HRID 2288281 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1(C([O-])=O)[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8]1.[Na+].Cl>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 70240266Sodium 2-(2-pyridinyl)-4-carboxyquinoline carboxylate

Product 1

HCID 241032-(Pyridin-2-yl)quinoline-4-carboxylic acid

Procedure

The free acid is prepared by neutralizing an aqueous solution of the sodium 2-(2-pyridyl)4-carboxyquinoline carboxylate 3 with 10% HCl. The acid is somewhat soluble in acidic solution, and care should be taken not to overacidify; a pH of 7 is optimum. The solid is filtered, washed with 40 mL of acetone and allowed to air dry.

Workup

  1. customThe free acid is prepared
  2. filtrationThe solid is filtered
  3. washwashed with 40 mL of acetone
  4. customto air dry

Sources & evidence

ORD record
ord-3b0db61c08864bae99404ce7b2dc6dd3
Source dataset
uspto-grants-2000_07
Patent number
US06087510

Reaction notes

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