Hydrochloric Acid → HCID 18412397, compound

HRID 2288335Notes

Reaction equation

HRID 2288335 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]([CH2:30][CH2:31]C(OC)=O)[C:8]([C:10]1[N:15]=[C:14]2[N:16]=[C:17]([CH2:20][O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]#[N:29])=[CH:24][CH:23]=3)[N:18]([CH3:19])[C:13]2=[CH:12][CH:11]=1)=[O:9].Cl.[C:37](=[O:40])([O-])[O-:38].[NH4+:41].[NH4+].[CH2:43](O)[CH3:44]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]([CH2:30][CH2:31][C:37]([O:38][CH2:43][CH3:44])=[O:40])[C:8]([C:10]1[N:15]=[C:14]2[N:16]=[C:17]([CH2:20][O:21][C:22]3[CH:23]=[CH:24][C:25]([C:28](=[NH:29])[NH2:41])=[CH:26][CH:27]=3)[N:18]([CH3:19])[C:13]2=[CH:12][CH:11]=1)=[O:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 18412459HCID 18412459, compoundHCID 86755515Ammonium carbonate ethanol

Product 1

HCID 18412397HCID 18412397, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared by reacting 140 mg (0.3 mMol) of 1-methyl-2-[(4-cyanophenyl)oxymethyl]-imidazo[4,5-b]pyridin-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)-amide with ethanol saturated by hydrogen chloride and with ammonium carbonate/ethanol analogously to Example 1g. The resulting product was purified by chromatography over silica gel with dichloromethane/ethanol (19:1 to 4:1). Yield: 48 mg of white powder (36% of theory), C26H27N7O4 (501.57) Mass spectrum: (M+H)+ =502

Workup

  1. customPrepared
  2. customThe resulting product was purified by chromatography over silica gel with dichloromethane/ethanol (19:1 to 4:1)

Sources & evidence

ORD record
ord-1596c9e9be7749de87f3d021b617b595
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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