Hydrochloric Acid → HCID 18412321, compound

HRID 2288355Notes

Reaction equation

HRID 2288355 reaction equation
[CH2:1]([N:4]([CH2:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[C:5]([C:7]1[CH:8]=[CH:9][C:10]2[S:14][C:13]([CH2:15][NH:16][C:17]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=3)=[N:12][C:11]=2[CH:25]=1)=[O:6])[CH2:2][CH3:3].[ClH:33].C(O)C.C(=O)([O-])[O-].[NH4+:41].[NH4+]>C(O)(=O)C.C(Cl)Cl.C(O)C>[ClH:33].[CH2:1]([N:4]([CH2:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[C:5]([C:7]1[CH:8]=[CH:9][C:10]2[S:14][C:13]([CH2:15][NH:16][C:17]3[CH:22]=[CH:21][C:20]([C:23](=[NH:41])[NH2:24])=[CH:19][CH:18]=3)=[N:12][C:11]=2[CH:25]=1)=[O:6])[CH2:2][CH3:3]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 517111Ammonium CarbonateHCID 184124292-[N-(4-cyanophenyl)aminomethyl]benzothiazol-5-yl-carboxylic acid-N-(n-propyl)-N-(2-ethoxycarbonylethyl)amide

Product 1

HCID 18412321HCID 18412321, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 21584144Dichloromethane ethanolSolvent

Procedure

Prepared analogously to Example 9 from 2-[N-(4-cyanophenyl)-aminomethyl]-benzothiazol-5-yl-carboxylic acid-N-(n-propyl)-N-(2-ethoxycarbonylethyl)-amide, ethanolic hydrochloric acid, ethanol and ammonium carbonate. Yield: 83% of theory, C24H29N5O3 (467.59) Rf value: 0.31 (silica gel; methylene chloride/ethanol=4:1+a few drops of acetic acid) ##EQU6##

Sources & evidence

ORD record
ord-b412b3f403c345c989776e93cfe3d4c6
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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