Hydrochloric Acid → HCID 18412487, compound

HRID 2288493Notes

Reaction equation

HRID 2288493 reaction equation
[C:1]1([N:7]([CH2:30]CC(OC)=O)[C:8]([C:10]2[CH:11]=[C:12]3[N:18]=[C:17]([CH2:19][NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][CH:22]=4)[N:16]([CH3:29])[C:13]3=[N:14][CH:15]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:36].C(=O)([O-])[O-].[NH4+:41].[NH4+].[C:43]([O:46][CH2:47][CH3:48])(=[O:45])[CH3:44].C(O)C.N>C(O)C>[ClH:36].[C:1]1([N:7]([CH2:30][CH2:44][C:43]([O:46][CH2:47][CH3:48])=[O:45])[C:8]([C:10]2[CH:11]=[C:12]3[N:18]=[C:17]([CH2:19][NH:20][C:21]4[CH:22]=[CH:23][C:24]([C:27](=[NH:28])[NH2:41])=[CH:25][CH:26]=4)[N:16]([CH3:29])[C:13]3=[N:14][CH:15]=2)=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 517111Ammonium CarbonateHCID 18412308HCID 18412308, compoundHCID 86587043Ethyl acetate ethanol ammonia

Product 1

HCID 18412487HCID 18412487, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 1 from 3-methyl-2-[N-(4-cyanophenyl)-aminomethyl]-imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide, ethanolic hydrochloric acid, ethanol and ammonium carbonate. Yield: 82% of theory, C27H29N7O3 (499.58) Rf value: 0.20 (silica gel; ethyl acetate/ethanol/ammonia=50:45:5) ##EQU107##

Sources & evidence

ORD record
ord-aa8f70f1bd2a45739e6f219f83fac584
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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