Sodium Hydroxide → HCID 18412628, compound

HRID 2288522Notes

Reaction equation

HRID 2288522 reaction equation
[ClH:1].[C:2]1([N:8]([CH2:32][CH2:33][C:34]([O:36]CC)=[O:35])[C:9]([C:11]2[CH:16]=[CH:15][N:14]3[C:17]([CH3:31])=[C:18]([CH2:20][CH2:21][C:22]4[CH:27]=[CH:26][C:25]([C:28](=[NH:30])[NH2:29])=[CH:24][CH:23]=4)[N:19]=[C:13]3[CH:12]=2)=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].C(OCC)(=O)C.C(O)C.N>>[ClH:1].[C:2]1([N:8]([CH2:32][CH2:33][C:34]([OH:36])=[O:35])[C:9]([C:11]2[CH:16]=[CH:15][N:14]3[C:17]([CH3:31])=[C:18]([CH2:20][CH2:21][C:22]4[CH:23]=[CH:24][C:25]([C:28](=[NH:29])[NH2:30])=[CH:26][CH:27]=4)[N:19]=[C:13]3[CH:12]=2)=[O:10])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 18412564HCID 18412564, compoundHCID 86587043Ethyl acetate ethanol ammonia

Product 1

HCID 18412628HCID 18412628, compoundYield 92%

Procedure

Prepared analogously to Example 2 from 3-methyl-2-[2-(4-amidinophenyl)ethyl]-imidazo[1.2-a]pyridin-7-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and sodium hydroxide solution. Yield: 92% of theory, C27H27N5O3 (469.55) Rf value: 0.19 (silica gel; ethyl acetate/ethanol/ammonia=50:45:5) ##EQU119##

Sources & evidence

ORD record
ord-dc41be6a7124433da7801fedadb4ee1f
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

Loading…