Sodium Hydroxide → HCID 140409620, compound

HRID 2288536Notes

Reaction equation

HRID 2288536 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]([CH2:41][CH2:42][C:43]([O:45]CC)=[O:44])[C:8]([C:10]1[CH:40]=[CH:39][C:13]2[N:14]([CH3:38])[C:15]([CH2:17][NH:18][C:19]3[CH:24]=[CH:23][C:22]([C:25](=[NH:37])[NH:26][C:27]([O:29][CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[O:28])=[CH:21][CH:20]=3)=[N:16][C:12]=2[CH:11]=1)=[O:9].[OH-].[Na+]>ClCCl.CO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]([CH2:41][CH2:42][C:43]([OH:45])=[O:44])[C:8]([C:10]1[CH:40]=[CH:39][C:13]2[N:14]([CH3:38])[C:15]([CH2:17][NH:18][C:19]3[CH:20]=[CH:21][C:22]([C:25](=[NH:37])[NH:26][C:27]([O:29][CH2:30][C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)=[O:28])=[CH:23][CH:24]=3)=[N:16][C:12]=2[CH:11]=1)=[O:9]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 140409598HCID 140409598, compound

Product 1

HCID 140409620HCID 140409620, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 104 from 1-methyl-2-[N-[4-(N-benzyloxycarbonylamidino)phenyl]-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide and sodium hydroxide solution. Yield: 62% of theory, C33H31N7O5 (605.7) Rf value: 0.26 (silica gel; dichloromethane/methanol=9:1) ##EQU133##

Sources & evidence

ORD record
ord-d519fafc6fc6412c85a37dac4ad9b3a2
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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