Hydroxylamine → HCID 178480671, compound

HRID 2288541Notes

Reaction equation

HRID 2288541 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]([CH2:30][CH2:31][C:32]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])=[O:33])[C:8]([C:10]1[CH:29]=[CH:28][C:13]2[N:14]([CH3:27])[C:15]([CH2:17][NH:18][C:19]3[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=3)=[N:16][C:12]=2[CH:11]=1)=[O:9].[NH2:39][OH:40].ClCCl.C(O)C>C(O)(=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]([CH2:30][CH2:31][C:32]([NH:34][S:35]([CH3:38])(=[O:36])=[O:37])=[O:33])[C:8]([C:10]1[CH:29]=[CH:28][C:13]2[N:14]([CH3:27])[C:15]([CH2:17][NH:18][C:19]3[CH:20]=[CH:21][C:22]([C:25](=[NH:26])[NH:39][OH:40])=[CH:23][CH:24]=3)=[N:16][C:12]=2[CH:11]=1)=[O:9]

Participants

5

Reactant 3

HCID 787HydroxylamineHCID 184125901-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-[2-(methanesulfonylaminocarbonyl)ethyl]amideHCID 21584144Dichloromethane ethanol

Product 1

HCID 178480671HCID 178480671, compoundYield 27%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Prepared analogously to Example 96 from 1-methyl-2-[N-(4-cyanophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-[2-(methanesulphonylaminocarbonyl)-ethyl]-amide and hydroxylamine. Yield: 27% of theory, C26H28N8O5S (564.6) Rf value: 0.75 (silica gel; dichloromethane/ethanol=7:3+1% glacial acetic acid) ##EQU137##

Sources & evidence

ORD record
ord-641ba20b92fc4053851c513186af72fa
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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