HRID2288545

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1cnc(C(=N)N)cn1)n2C)c1ccccn1.Cl

HCID18412599

未命名化合物

PRODUCTS

生成物

结构：Cn1c(CNc2cnc(C(=N)N)cn2)nc2cc(C(=O)N(CCC(=O)O)c3ccccn3)ccc21

HCID18412381

未命名化合物

收率 11%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Prepared analogously to Example 26 from 1-methyl-2-[N-(2-amidino-pyrazin-5-yl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and sodium hydroxide solution. Yield: 11% of theory, C23H23N9O3 (473.5) Rf value: 0.55 (Reversed Phase silica gel RP-8; 5% saline solution/methanol=6:4) ##EQU139##