Hexyl chloroformate → hexyl (NZ)-N-[amino-[4-[2-[1-methyl-5-[phenyl-[2-(2H-tetrazol-5-yl)ethyl]carbamoyl]benzimidazol-2-yl]ethyl]phenyl]methylidene]carbamate

HRID 2288546Notes

Reaction equation

HRID 2288546 reaction equation
[C:1]1([N:7]([CH2:31][CH2:32][C:33]2[NH:37][N:36]=[N:35][N:34]=2)[C:8]([C:10]2[CH:30]=[CH:29][C:13]3[N:14]([CH3:28])[C:15]([CH2:17][CH2:18][C:19]4[CH:24]=[CH:23][C:22]([C:25](=[NH:27])[NH2:26])=[CH:21][CH:20]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:39]([O:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])=[O:40]>ClCCl.CO>[C:1]1([N:7]([CH2:31][CH2:32][C:33]2[NH:37][N:36]=[N:35][N:34]=2)[C:8]([C:10]2[CH:30]=[CH:29][C:13]3[N:14]([CH3:28])[C:15]([CH2:17][CH2:18][C:19]4[CH:20]=[CH:21][C:22]([C:25](=[NH:26])[NH:27][C:39]([O:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])=[O:40])=[CH:23][CH:24]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 22466Hexyl chloroformateHCID 178480190HCID 178480190, compound

Product 1

HCID 178445089hexyl (NZ)-N-[amino-[4-[2-[1-methyl-5-[phenyl-[2-(2H-tetrazol-5-yl)ethyl]carbamoyl]benzimidazol-2-yl]ethyl]phenyl]methylidene]carbamate

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 90 from 1-methyl-2-[2-(4-amidinophenyl)-ethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-[2-(1H-tetrazol-5-yl)-ethyl]-amide and n-hexyl chloroformate. Yield: % of theory, C34H39N9O3 (621.7) Rf value: (silica gel; dichloromethane/methanol=4:1)

Sources & evidence

ORD record
ord-6a7f2fa6eedd4f6f96e6d8c077f95ef7
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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