4-Chlorobenzaldehyde → 7-(4-Chlorophenyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

Participants

Reaction Steps

2-(3-Thienyl)ethanamine (3.15 g) and 4-chlorobenzaldehyde (3.5 g) were mixed without solvent resulting in dissolution af the crystals of the amine followed by precipitation of slightly yellow crystals. The mixture was left at RT for 4 h. Trifluoroacetic acid (20 ml) was added and the mixture stirred overnight at RT.

Provenance & Evidence