2-Aminopyridine → HCID 15453908, compound

HRID 2288614Notes

Reaction equation

HRID 2288614 reaction equation
Br[CH2:2][C:3]([C:5]1[S:9][C:8]([CH2:10][N:11]2[C:15](=[O:16])[C:14]3=[CH:17][CH:18]=[CH:19][CH:20]=[C:13]3[C:12]2=[O:21])=[CH:7][CH:6]=1)=O.[NH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1>C(O)C>[C:15]1(=[O:16])[N:11]([CH2:10][C:8]2[S:9][C:5]([C:3]3[N:22]=[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]4[CH:2]=3)=[CH:6][CH:7]=2)[C:12](=[O:21])[C:13]2=[CH:20][CH:19]=[CH:18][CH:17]=[C:14]12

Participants

4

Reactant 2

HCID 104392-AminopyridineHCID 15453907HCID 15453907, compound

Product 1

HCID 15453908HCID 15453908, compoundYield 48.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Bromoacetyl-2-(phthalimidomethyl)thiophene (0.80 g) and 2-aminopyridine (0.23 g) were dissolved in anhydrous ethanol (50 ml) and heated under reflux for 6 hours. The resulting crystals were collected by filtration and purified by a silica gel column chromatography (chloroform:methanol=100:1) to give 0.38 g of the title compound.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 6 hours
  3. filtrationThe resulting crystals were collected by filtration
  4. custompurified by a silica gel column chromatography (chloroform:methanol=100:1)

Sources & evidence

ORD record
ord-5d6e879fbf9248ecba785528d4f2c017
Source dataset
uspto-grants-2000_07
Patent number
US06090804

Reaction notes

Loading…