反应详情

4.5 g of 2-phenyl-6-(acetoxymethyl)-pyridine (20 mmol) was treated with an aqueous HCl solution (15%, 10 ml) and the mixture was heated at reflux temperature while stirring. After 30 minutes the reaction mixture was concentrated with the aid of an oil pump (10 mm) at 40° C., CH3CN was added, and the mixture was evaporated to dryness in vacuo and yielded 2-phenyl-6-(hydroxymethyl)-pyridine (3.0 g, 80%) as an oil.

1. temperaturethe mixture was heated
2. temperatureat reflux temperature
3. concentrationAfter 30 minutes the reaction mixture was concentrated with the aid of an oil pump (10 mm) at 40° C.
4. additionCH3CN was added
5. customthe mixture was evaporated to dryness in vacuo