Methane → HCID 15462259, compound

HRID 2288662Notes

Reaction equation

HRID 2288662 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[C:6](=[O:16])[NH:5][C:4](=[O:17])[C:3]=1[NH:18][CH:19]=O.C>[OH-].[Na+].O>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][N:7]2[C:2]3[N:1]=[CH:19][NH:18][C:3]=3[C:4](=[O:17])[NH:5][C:6]2=[O:16])=[CH:10][CH:11]=1

Participants

5

Reactant 2

HCID 297MethaneHCID 18432829HCID 18432829, compound

Product 1

HCID 15462259HCID 15462259, compoundYield 95.4%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

6-Amino-1-(4-chlorobenzyl)-5-formylamino-uracil (25.58 g) in 200 ml of 2N NaOH and 150 ml of water was heated under reflux for 3 hours. Charcoal (2.6 g) was added, and after filtration the solution was neutralized to pH 7.0 and the solid collected. Reprecipitation from NaOH by neutralization with HCl gave 22.91 g of title compound as a white solid mp 304-10° C.

Workup

  1. temperatureunder reflux for 3 hours
  2. filtrationafter filtration the solution
  3. customthe solid collected
  4. customReprecipitation from NaOH by neutralization with HCl

Sources & evidence

ORD record
ord-4b8bfdc139064677840a1b50928bbd04
Source dataset
uspto-grants-2000_07
Patent number
US06090816

Reaction notes

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