反应详情

6-Benzyloxy-4-chloro-7-methoxy-quinoline (525 mg) was dissolved in triethylamine/N,N-dimethylformamide (5 ml/20 ml) to prepare a solution. 20% palladium hydroxide (1.52 g) was added to the solution, and the mixture was stirred at room temperature under a hydrogen gas atmosphere for 6 hr. The reaction solution was filtered, and the solvent was then removed by distillation under the reduced pressure. Water was added to the residue, the mixture was extracted with chloroform, and the chloroform layer was then washed with water and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by column chromatography using acetone-chloroform to give 6-hydroxy-7-methoxyquinoline (258 mg, yield 84%).

1. customto prepare a solution
2. filtrationThe reaction solution was filtered
3. customthe solvent was then removed by distillation under the reduced pressure
4. additionWater was added to the residue
5. extractionthe mixture was extracted with chloroform
6. washthe chloroform layer was then washed with water
7. dry with materialwas dried over anhydrous sodium sulfate
8. customThe solvent was removed by distillation under the reduced pressure
9. customthe residue was purified by column chromatography