反应详情

温度

160 °C

6-Methoxy-7-methylisoquinoline (239 mg) and sodium thiomethoxide (1.58 g) were suspended in N,N-dimethylformamide (12 ml), and the suspension was stirred at 160° C. for 2 hr. The reaction solution was cooled to room temperature, the reaction solution was then filtered, and the solvent was removed from the filtrate by distillation under the reduced pressure. The residue was purified by thin layer chromatography using chloroform-methanol to give 6-hydroxy-7-methylisoquinoline (21 mg, yield 1%).

1. temperatureThe reaction solution was cooled to room temperature
2. filtrationthe reaction solution was then filtered
3. customthe solvent was removed from the filtrate by distillation under the reduced pressure
4. customThe residue was purified by thin layer chromatography