Thioacetamide → HCID 9954385, compound

HRID 2288773Notes

Reaction equation

[Br:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=3)[CH:8]=2)[C:3]1=[O:21].[C:22]([NH2:25])(=[S:24])[CH3:23]>CC(C)=O>[BrH:1].[CH3:23][C:22]1[S:24][CH:2]2[CH2:10][C:9]3[CH:8]=[C:7]([C:11]4[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=4)[CH:6]=[CH:5][C:4]=3[C:3]2([OH:21])[N:25]=1

Participants

Conditions

Temperature: 0 °C

Procedure

213 mg of 2-bromo-5-(3-trifluoromethylphenyl)indan-1-one and 48.8 mg of thioacetamide are dissolved in 10 ml of dry acetone and the solution is stirred at 0° C. for 8 h. The precipitate is filtered off with suction, washed with acetone and dried in a high vacuum. 2-Methyl-6-(3-trifluoromethylphenyl)-8,8a-dihydroindeno[1,2-d]thiazol-3a-ol hydrobromide of melting point 245-250° C. (dec.) is obtained.

Workup

filtrationThe precipitate is filtered off with suction
washwashed with acetone
customdried in a high vacuum

Sources & evidence

ORD record: ord-60d93190dccb46679984a998130514f0
Source dataset: uspto-grants-2000_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06090833

Reaction notes

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