反应详情

温度

150 °C

7-Bromo-6-methoxyisoquinoline (50 mg) and sodium thiomethoxide (147 mg) were suspended in N,N-dimethylformamide (2 ml), and the suspensioin was stirred at 150° C. for 2 hr. The reaction solution was cooled to room temperature, the reaction solution was then filtered, and the solvent was removed from the filtrate by distillation under the reduced pressure. The residue was purified by thin layer chromatography using chloroform-methanol to give 7-bromo-6-hydroxyisoquinoline (11 mg, yield 22%).

1. temperatureThe reaction solution was cooled to room temperature
2. filtrationthe reaction solution was then filtered
3. customthe solvent was removed from the filtrate by distillation under the reduced pressure
4. customThe residue was purified by thin layer chromatography