3-Nitrophenylethyl alcohol → 2-(3-nitrophenyl)acetaldehyde

HRID 2288786Notes

Reaction equation

HRID 2288786 reaction equation
I(C1C=CC=CC=1C(O)=O)(=O)=O.[N+:13]([C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][OH:24])[CH:19]=[CH:20][CH:21]=1)([O-:15])=[O:14]>O1CCCC1>[N+:13]([C:16]1[CH:17]=[C:18]([CH2:22][CH:23]=[O:24])[CH:19]=[CH:20][CH:21]=1)([O-:15])=[O:14]

Participants

4

Reactant 2

HCID 1040583-Nitrophenylethyl alcoholHCID 1087942-Iodoxybenzoic acid

Product 1

HCID 115284082-(3-nitrophenyl)acetaldehyde

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

90 mmol of iodoxybenzoic acid are added to 60 mmol of 2-(3-nitrophenyl)ethanol in 300 ml of tetrahydrofuran. The reaction mixture is heated at reflux for 4 hours, then cooled and filtered. The filtrate is concentrated to yield the expected compound.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 4 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. concentrationThe filtrate is concentrated

Sources & evidence

ORD record
ord-4688395c9c144cceae85a8616aa9c1ed
Source dataset
uspto-grants-2000_07
Patent number
US06090837

Reaction notes

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