4-Acetylbenzoic Acid → 4-Acetylbenzoyl chloride

HRID 2288790Notes

Reaction equation

HRID 2288790 reaction equation
S(Cl)([Cl:3])=O.[C:5]([C:8]1[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=1)(=[O:7])[CH3:6]>C1(C)C=CC=CC=1>[C:5]([C:8]1[CH:16]=[CH:15][C:11]([C:12]([Cl:3])=[O:13])=[CH:10][CH:9]=1)(=[O:7])[CH3:6]

Participants

4

Reactant 2

HCID 114704-Acetylbenzoic AcidHCID 24386Thionyl Chloride

Product 1

HCID 134096034-Acetylbenzoyl chloride

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

120 mmol of thionyl chloride are added to 600 mmol of 4-acetylbenzoic acid in 150 ml of toluene. The reaction mixture is heated at reflux for 3 hours and then cooled. The solvent is evaporated off. The product is used without any other treatment.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 3 hours
  3. temperaturecooled
  4. customThe solvent is evaporated off

Sources & evidence

ORD record
ord-719fe9b2a7304aab88ae7cba14527f68
Source dataset
uspto-grants-2000_07
Patent number
US06090837

Reaction notes

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