反应详情

温度

80 °C

6-Hydroxy-7-methylquinoline (76 mg) was dissolved in chlorobenzene (7 ml) to prepare a solution. N-Bromosuccimide (180 mg) and 2,2′-azobisisobutyronitrile (23 mg) were added to the solution, and the mixture was stirred at 80° C. for one hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was then washed with water and was dried over anhydrous sodium sulfate, the solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using acetone-chloroform to give 5-bromo-6-hydroxy-7-methyl-quinoline (111 mg, yield 97%).

1. customto prepare a solution
2. extractionthe mixture was extracted with ethyl acetate
3. washThe ethyl acetate layer was then washed with water
4. dry with materialwas dried over anhydrous sodium sulfate
5. customthe solvent was removed by distillation under the reduced pressure
6. customthe residue was purified by thin layer chromatography