Ethanethiol → HCID 21702002, compound

HRID 2288918Notes

Reaction equation

HRID 2288918 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][O:21][C:22](=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24])=[CH:15][CH:14]=3)=[O:12])=[C:9]([C:28]3[CH:33]=[CH:32][C:31]([O:34]C)=[CH:30][CH:29]=3)[S:8][C:7]=2[CH:36]=1.C(S)C.[Cl-].[Al+3].[Cl-].[Cl-]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:14]=[CH:15][C:16]([O:19][CH2:20][O:21][C:22](=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24])=[CH:17][CH:18]=3)=[O:12])=[C:9]([C:28]3[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=3)[S:8][C:7]=2[CH:36]=1

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 6451240Aluminum(III) ChlorideHCID 21701999HCID 21701999, compound

Product 1

HCID 21702002HCID 21702002, compoundYield 69%

Procedure

[6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thiophen-3-yl][4-(Trimethylacetoxymethoxy)phenyl]methanone (760 mg, 1.5 mmol) was converted to the title compound by the procedure of Example 3 using 300 mg (4.5 mmol) of ethanethiol and 600 mg (4.5 mmol) of aluminum chloride.

Sources & evidence

ORD record
ord-6c545075d6b548ebb344aca7561870de
Source dataset
uspto-grants-2000_07
Patent number
US06090843

Reaction notes

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