Ethanethiol → HCID 15888351, compound

HRID 2288919Notes

Reaction equation

HRID 2288919 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]([OH:30])[CH2:22][N:23]4[CH2:28][CH2:27][CH2:26][CH:25]([CH3:29])[CH2:24]4)=[CH:15][CH:14]=3)=[O:12])=[C:9]([C:31]3[CH:36]=[CH:35][C:34]([O:37]C)=[CH:33][CH:32]=3)[S:8][C:7]=2[CH:39]=1.C(S)C.[Cl-].[Al+3].[Cl-].[Cl-]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH:21]([OH:30])[CH2:22][N:23]4[CH2:28][CH2:27][CH2:26][CH:25]([CH3:29])[CH2:24]4)=[CH:17][CH:18]=3)=[O:12])=[C:9]([C:31]3[CH:32]=[CH:33][C:34]([OH:37])=[CH:35][CH:36]=3)[S:8][C:7]=2[CH:39]=1

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 6451240Aluminum(III) ChlorideHCID 15888350HCID 15888350, compound

Product 1

HCID 15888351HCID 15888351, compoundYield 66%

Procedure

[6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-(2-hydroxy-3-[3-methylpiperidinyl]propoxy)phenyl]methanone (540 mg, 1.0 mmol) was converted to 340 mg of the title compound by the procedure of Example 32 using 360 mg (4.9 mmol) of ethanethiol and aluminum chloride.

Sources & evidence

ORD record
ord-aaee0186f7cf415db53cee21b8055286
Source dataset
uspto-grants-2000_07
Patent number
US06090843

Reaction notes

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