HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N2 (tert-butoxycarbonyl)-N2-(iminomethoxymethyl)-L-lysine tert-butyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | N2 (tert-butoxycarbonyl)-N5-(iminomethoxymethyl)-L-ornithine tert-butyl ester hydrochloride | HCID 86755535 | — |
| Reactant | N2 (tert-butoxycarbonyl)-N6-(cyano)-L-lysine tert-butyl ester | HCID 131721879 | — |
| Reactant | HCID 178475095 | HCID 178475095 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N2 (tert-butoxycarbonyl)-N2-(iminomethoxymethyl)-L-lysine tert-butyl ester hydrochloride | HCID 131721877 | — |
Reaction Steps
From 1.6 g (4.89 mmol) N2 -(tert-butoxycarbonyl)-N6 -(cyano)-L-lysine tert-butyl ester was prepared 1.5 g (75%) of foamy solid N2 -(tert-butoxycarbonyl)-N6 -(ethoxyiminomethyl)-L-lysine tert-butyl ester hydrochloride by the method described for N2 -(tert-butoxycarbonyl)-N5 -(iminomethoxymethyl)-L-ornithine tert-butyl ester hydrochloride. TLC (methanol:dichloromethane/1:9) Rf=0.36. Mass spectrum (CI) 360 (MH+, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06090846 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-e69960578289401e952f5aef22f15d7f |
| Source note | uspto-grants-2000_07 |