反应详情

A solution of 4-[5-(4-Chlorophenyl)-4-(2,2,2-trifluoroethoxymethyl)-oxazol-2-yl]-piperidine-1-carboxylic acid benzyl ester (3.7600 g, 7.3880 mmol) in trifluoroacetic acid (10 mL, 130 mmol) was stirred at RT for 3 d, then concentrated to a thick oil. This is dissolved with heating in a mixture of hexane and diethyl ether which, upon cooling, precipitated cream-colored solids. These are collected, washed with hexane and dried in vacuo at RT. Reworking the mother liquors gives a second crop of solids. The crops are combined to give the title compound as cream colored solids.

1. concentrationconcentrated to a thick oil
2. dissolutionThis is dissolved
3. temperaturewith heating in a mixture of hexane and diethyl ether which
4. temperatureupon cooling
5. customprecipitated cream-colored solids
6. customThese are collected
7. washwashed with hexane
8. customdried in vacuo at RT
9. customReworking the mother liquors gives a second crop of solids