反应详情

温度

150 °C

1-(2-chloroethyl)-4-methoxybenzene (486 mg, 2.8 mmol), 4-(4-ethoxymethyl-5-phenyl-oxazol-2-yl)-piperidine hydrochloride (1 g, 2.2 mmol), prepared as in Intermediate 4, K2CO3 (393 mg, 2.85 mmol) and Nal (427 mg, 2.85 mmol) in ethanol are mixed together in a sealed tube and heated to 150° C. overnight. The mixture is cooled, filtered and concentrated. The crude material is purified by column chromatography (SiO2, 10% methanol: methylene chloride), followed by another column (SiO2, 15% methanol: ethyl acetate) to afford an oil which is triturated from 70% hexane; ether, 800 mg of the title compound is obtained.

1. additionare mixed together in a sealed tube
2. temperatureThe mixture is cooled
3. filtrationfiltered
4. concentrationconcentrated
5. customThe crude material is purified by column chromatography (SiO2, 10% methanol: methylene chloride)
6. customto afford an oil which
7. customis triturated from 70% hexane