反应详情

4-Amino-pyridine-3-carbaldehyde (1.0 g) and chloroacetone (0.7 g) were suspended in a 5 N aqueous sodium hydroxide solution (5 ml), and the suspension was allowed to stand in a sealed tube for 3 days. The reaction solution was neutralized with 10% hydrochloric acid, and the precipitated crystal was then collected by filtration. Isopropanol was added to the collected crystal, and the mixture was heated under reflux. The reaction solution was cooled to room temperature, and the solvent was then removed by distillation. Hexane was added to the residue, and the precipitated crystal was collected by filtration and was washed with hexane to give 2-methyl-[1,6]naphthyridin-3-ol (0.60 g, yield 46%).

1. filtrationthe precipitated crystal was then collected by filtration
2. additionIsopropanol was added to the collected crystal
3. temperaturethe mixture was heated
4. temperatureunder reflux
5. customthe solvent was then removed by distillation
6. additionHexane was added to the residue
7. filtrationthe precipitated crystal was collected by filtration
8. washwas washed with hexane