Trifluoroacetic acid → HCID 178462043, compound

HRID 2289061Notes

Reaction equation

HRID 2289061 reaction equation
[N+:1]([C:4]1[CH:43]=[CH:42][C:7]([CH2:8][O:9][C:10]([N:12]=[C:13]([NH:28][C:29]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][C:36]([N+:39]([O-:41])=[O:40])=[CH:35][CH:34]=2)=[O:30])[NH:14][C@@H:15]([CH3:27])[C:16]([NH:18][C@H:19]2[CH2:23][CH2:22][N:21](C([O-])=O)[CH2:20]2)=[O:17])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47]>ClCCl>[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47].[N+:1]([C:4]1[CH:43]=[CH:42][C:7]([CH2:8][O:9][C:10]([N:12]=[C:13]([NH:28][C:29]([O:31][CH2:32][C:33]2[CH:34]=[CH:35][C:36]([N+:39]([O-:41])=[O:40])=[CH:37][CH:38]=2)=[O:30])[NH:14][C@@H:15]([CH3:27])[C:16]([NH:18][C@H:19]2[CH2:23][CH2:22][NH:21][CH2:20]2)=[O:17])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178462046HCID 178462046, compound

Product 1

HCID 178462043HCID 178462043, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the compound (1.59 g), which had been obtained in (1), in anhydrous dichloromethane (6 ml), trifluoroacetic acid (3 ml) was added dropwise under ice cooling. The reaction mixture was then treated in a similar manner to that described in Referential Example 16-(2), whereby the title compound was obtained. The product was provided for use in the subsequent reaction without isolation.

Workup

  1. additionThe reaction mixture was then treated in a similar manner to that

Sources & evidence

ORD record
ord-ac3f2d15beb241f18d644cd71c385f92
Source dataset
uspto-grants-2000_07
Patent number
US06090802

Reaction notes

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