HCID 54574361, compound → HCID 178462041, compound

HRID 2289063Notes

Reaction equation

HRID 2289063 reaction equation
[NH2:1][C@@H:2]([CH3:17])[C:3]([NH:5][CH:6]1[CH2:9][N:8]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:7]1)=[O:4].[N+:18]([C:21]1[CH:51]=[CH:50][C:24]([CH2:25][O:26][C:27]([N:29]=[C:30]([NH:36][C:37](=[O:49])[O:38][CH2:39][C:40]2[CH:45]=[CH:44][C:43]([N+:46]([O-:48])=[O:47])=[CH:42][CH:41]=2)N2C=CC=N2)=[O:28])=[CH:23][CH:22]=1)([O-:20])=[O:19]>O1CCCC1>[N+:18]([C:21]1[CH:22]=[CH:23][C:24]([CH2:25][O:26][C:27]([N:29]=[C:30]([NH:36][C:37]([O:38][CH2:39][C:40]2[CH:45]=[CH:44][C:43]([N+:46]([O-:48])=[O:47])=[CH:42][CH:41]=2)=[O:49])[NH:1][C@@H:2]([CH3:17])[C:3]([NH:5][CH:6]2[CH2:9][N:8]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:7]2)=[O:4])=[O:28])=[CH:50][CH:51]=1)([O-:20])=[O:19]

Participants

4

Reactant 2

HCID 54574361HCID 54574361, compoundHCID 57274558HCID 57274558, compound

Product 1

HCID 178462041HCID 178462041, compoundYield 98.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of tert-butyl 3-[(2S)-2-amino-2-methylacetylamino]-1-azetidinecarboxylate (557 mg) in anhydrous tetrahydrofuran (10 ml), a solution of 4-nitrobenzyl [(4-nitrobenzyloxy)carbonylimino-pyrazol-1-ylmethyl]carbamate (974 mg) in tetrahydrofuran (20 ml) was added. The reaction mixture was then treated in a similar manner to that described in Referential Example 16-(1), whereby 1.32 g of the title compound were obtained as an amorphous substance.

Workup

  1. additionThe reaction mixture was then treated in a similar manner to that

Sources & evidence

ORD record
ord-3dd715407e2e49e8839d09739bb4a67a
Source dataset
uspto-grants-2000_07
Patent number
US06090802

Reaction notes

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