HCID 54574361, compound → HCID 178462047, compound

HRID 2289066Notes

Reaction equation

HRID 2289066 reaction equation
[NH2:1][C@H:2]([CH3:18])[C:3]([NH:5][C@H:6]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7]1)=[O:4].[N+:19]([C:22]1[CH:52]=[CH:51][C:25]([CH2:26][O:27][C:28]([N:30]=[C:31]([NH:37][C:38](=[O:50])[O:39][CH2:40][C:41]2[CH:46]=[CH:45][C:44]([N+:47]([O-:49])=[O:48])=[CH:43][CH:42]=2)N2C=CC=N2)=[O:29])=[CH:24][CH:23]=1)([O-:21])=[O:20]>O1CCCC1>[N+:19]([C:22]1[CH:23]=[CH:24][C:25]([CH2:26][O:27][C:28]([N:30]=[C:31]([NH:37][C:38]([O:39][CH2:40][C:41]2[CH:46]=[CH:45][C:44]([N+:47]([O-:49])=[O:48])=[CH:43][CH:42]=2)=[O:50])[NH:1][C@H:2]([CH3:18])[C:3]([NH:5][C@H:6]2[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7]2)=[O:4])=[O:29])=[CH:51][CH:52]=1)([O-:21])=[O:20]

Participants

4

Reactant 2

HCID 54574361HCID 54574361, compoundHCID 57302804HCID 57302804, compound

Product 1

HCID 178462047HCID 178462047, compoundYield 100.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of tert-butyl (3S)-3-[(2R)-2-amino-2-methylacetylamino]-1-pyrrolidinecarboxylate (448 mg) in anhydrous tetrahydrofuran (20 ml), 4-nitrobenzyl [(4-nitrobenzyloxy)carbonylimino-pyrazol-1-ylmethyl]carbamate (776 mg) was added under ice cooling. The resulting mixture was treated in a similar manner to that described in Referential Example 16-(1), whereby the title compound (1.096 g) was obtained as an amorphous substance.

Workup

  1. additionThe resulting mixture was treated in a similar manner to that

Sources & evidence

ORD record
ord-86d4c7d0fc4a4166ab9faf098d090a5e
Source dataset
uspto-grants-2000_07
Patent number
US06090802

Reaction notes

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