Trifluoroacetic acid → HCID 178462042, compound

HRID 2289067Notes

Reaction equation

HRID 2289067 reaction equation
[N+:1]([C:4]1[CH:47]=[CH:46][C:7]([CH2:8][O:9][C:10]([N:12]=[C:13]([NH:32][C:33]([O:35][CH2:36][C:37]2[CH:42]=[CH:41][C:40]([N+:43]([O-:45])=[O:44])=[CH:39][CH:38]=2)=[O:34])[NH:14][C@H:15]([CH3:31])[C:16]([NH:18][C@H:19]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20]2)=[O:17])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:48][C:49]([F:54])([F:53])[C:50]([OH:52])=[O:51]>ClCCl>[F:48][C:49]([F:54])([F:53])[C:50]([OH:52])=[O:51].[N+:1]([C:4]1[CH:47]=[CH:46][C:7]([CH2:8][O:9][C:10]([N:12]=[C:13]([NH:32][C:33]([O:35][CH2:36][C:37]2[CH:38]=[CH:39][C:40]([N+:43]([O-:45])=[O:44])=[CH:41][CH:42]=2)=[O:34])[NH:14][C@H:15]([CH3:31])[C:16]([NH:18][C@H:19]2[CH2:23][CH2:22][NH:21][CH2:20]2)=[O:17])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178462047HCID 178462047, compound

Product 1

HCID 178462042HCID 178462042, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the compound (1.087 g), which had been obtained in (1), in anhydrous dichloromethane (5 ml), trifluoroacetic acid (2 ml) was added dropwise under ice cooling. The resulting mixture was treated in a similar manner to that described in Referential Example 16-(2), whereby the title compound was obtained. The product was provided for use in the subsequent reaction without isolation, Infrared absorption spectrum (KBr) νmax cm-1 : 3290, 1739, 1674, 1645, 1625, 1555, 1524.

Workup

  1. additionThe resulting mixture was treated in a similar manner to that

Sources & evidence

ORD record
ord-a08044e24a77477fa7c7d41b04679be0
Source dataset
uspto-grants-2000_07
Patent number
US06090802

Reaction notes

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