HCID 54271042, compound → HCID 178462040, compound

HRID 2289069Notes

Reaction equation

HRID 2289069 reaction equation
[NH2:1][C@H:2]([CH3:17])[C:3]([NH:5][CH:6]1[CH2:9][N:8]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:7]1)=[O:4].[N+:18]([C:21]1[CH:51]=[CH:50][C:24]([CH2:25][O:26][C:27]([N:29]=[C:30]([NH:36][C:37](=[O:49])[O:38][CH2:39][C:40]2[CH:45]=[CH:44][C:43]([N+:46]([O-:48])=[O:47])=[CH:42][CH:41]=2)N2C=CC=N2)=[O:28])=[CH:23][CH:22]=1)([O-:20])=[O:19]>O1CCCC1>[N+:18]([C:21]1[CH:22]=[CH:23][C:24]([CH2:25][O:26][C:27]([N:29]=[C:30]([NH:36][C:37]([O:38][CH2:39][C:40]2[CH:45]=[CH:44][C:43]([N+:46]([O-:48])=[O:47])=[CH:42][CH:41]=2)=[O:49])[NH:1][C@H:2]([CH3:17])[C:3]([NH:5][CH:6]2[CH2:9][N:8]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:7]2)=[O:4])=[O:28])=[CH:50][CH:51]=1)([O-:20])=[O:19]

Participants

4

Reactant 2

HCID 54271042HCID 54271042, compoundHCID 54574361HCID 54574361, compound

Product 1

HCID 178462040HCID 178462040, compoundYield 76.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of tert-butyl 3-[(2R)-2-amino-2-methylacetylamino]-1-azetidinecarboxylate (443 mg) in anhydrous tetrahydrofuran (20 ml), 4-nitrobenzyl [(4-nitrobenzyloxy)carbonylimino-pyrazol-1-ylmethyl]carbamate (820 mg) was added under ice cooling. The resulting mixture was then treated in a similar manner to that described in Referential Example 16-(1), whereby the title compound (0.860 g) was obtained as an amorphous substance.

Workup

  1. additionThe resulting mixture was then treated in a similar manner to that

Sources & evidence

ORD record
ord-cf40fe41a9d84834b0becbd3e1ee8b21
Source dataset
uspto-grants-2000_07
Patent number
US06090802

Reaction notes

Loading…