Trifluoroacetic acid → HCID 73457551, compound

HRID 2289074Notes

Reaction equation

HRID 2289074 reaction equation
[CH3:1][N:2]([CH2:32][C:33]([NH:35][C@H:36]1C[CH2:39][N:38](C(OC(C)(C)C)=O)[CH2:37]1)=[O:34])[C:3]([NH:18][C:19]([O:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=1)=[O:20])=[N:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)=[O:6].[F:48][C:49]([F:54])([F:53])[C:50]([OH:52])=[O:51]>ClCCl>[F:48][C:49]([F:54])([F:53])[C:50]([OH:52])=[O:51].[N+:15]([C:12]1[CH:11]=[CH:10][C:9]([CH2:8][O:7][C:5]([N:4]=[C:3]([NH:18][C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=2)=[O:20])[N:2]([CH2:32][C:33]([NH:35][CH:36]2[CH2:37][NH:38][CH2:39]2)=[O:34])[CH3:1])=[O:6])=[CH:14][CH:13]=1)([O-:17])=[O:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57034816HCID 57034816, compound

Product 1

HCID 73457551HCID 73457551, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the compound (1.22 g), which had been obtained in (1), in anhydrous dichloromethane (12 ml), trifluoroacetic acid (6 ml) was added dropwise under ice cooling. The reaction mixture was then treated in a similar manner to that described in Referential Example 16-(2), whereby the title compound was obtained. The product was provided for use in the subsequent reaction without isolation.

Workup

  1. additionThe reaction mixture was then treated in a similar manner to that

Sources & evidence

ORD record
ord-9e7f8e216c81475184dbd4e2698f12b0
Source dataset
uspto-grants-2000_07
Patent number
US06090802

Reaction notes

Loading…