HCID 54574361, compound → HCID 178452033, compound

HRID 2289077Notes

Reaction equation

HRID 2289077 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]([NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9]1)=[O:6].[N+:20]([C:23]1[CH:53]=[CH:52][C:26]([CH2:27][O:28][C:29]([N:31]=[C:32]([NH:38][C:39](=[O:51])[O:40][CH2:41][C:42]2[CH:47]=[CH:46][C:45]([N+:48]([O-:50])=[O:49])=[CH:44][CH:43]=2)N2C=CC=N2)=[O:30])=[CH:25][CH:24]=1)([O-:22])=[O:21]>O1CCCC1>[N+:20]([C:23]1[CH:24]=[CH:25][C:26]([CH2:27][O:28][C:29]([N:31]=[C:32]([NH:38][C:39]([O:40][CH2:41][C:42]2[CH:47]=[CH:46][C:45]([N+:48]([O-:50])=[O:49])=[CH:44][CH:43]=2)=[O:51])[NH:1][CH2:2][CH2:3][CH2:4][C:5]([NH:7][C@H:8]2[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9]2)=[O:6])=[O:30])=[CH:52][CH:53]=1)([O-:22])=[O:21]

Participants

4

Reactant 2

HCID 54574361HCID 54574361, compoundHCID 57118482HCID 57118482, compound

Product 1

HCID 178452033HCID 178452033, compoundYield 109%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of tert-butyl (3S)-3-(4-aminobutanoylamino)-1-pyrrolidinecarboxylate (1.36 g) in anhydrous tetrahydrofuran (30 ml), 4-nitrobenzyl [(4-nitrobenzyloxy)carbonylimino-pyrazol-1-ylmethyl]carbamate (1.60 g) was added under ice cooling. The resulting (mixture was then treated in a similar manner to that described in Referential Example 16-(1), whereby the title compound (2.50 g) was obtained as an amorphous substance.

Workup

  1. additionThe resulting (mixture was then treated in a similar manner to that

Sources & evidence

ORD record
ord-127480e0abc64747ad6aefdd26905f74
Source dataset
uspto-grants-2000_07
Patent number
US06090802

Reaction notes

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