反应详情

温度

0 °C

A solution of Methyl 3-chloro-4-(3-(3-trifluoromethyl-7-propyl-6-benz-[4,5]-isoxazoloxy)propylamino)-phenylacetate (Step C, 0.113 grams) in methanol (1.5 mL) was treated with a solution of lithium hydroxide in water (1.01 M; 0.362 mL). The reaction was refluxed 1 hour. The reaction mixture was partitioned between isopropyl acetate and 0.1N HCl. The organic was dried over magnesium sulfate, filtered and concentrated to a solid. The solid was suspended in methylene chloride/cyclohexane (1:1; 2 mL). The mixture was refluxed briefly and cooled to 0° C. The title compound was isolated by filtration.

1. temperatureThe reaction was refluxed 1 hour
2. customThe reaction mixture was partitioned between isopropyl acetate and 0.1N HCl
3. dry with materialThe organic was dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated to a solid
6. temperatureThe mixture was refluxed briefly